4YZW

Crystal structure of AgPPO8

4YZW の概要

• エントリーDOI: 10.2210/pdb4yzw/pdb
• 分子名称: AGAP004976-PA, COPPER (II) ION (3 entities in total)
• 機能のキーワード: prophenoloxidase, ppo, type 3 copper enzyme, oxidoreductase
• 由来する生物種: Anopheles gambiae (African malaria mosquito)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 163901.04

構造登録者

Hu, Y. (登録日: 2015-03-25, 公開日: 2015-12-23, 最終更新日: 2024-10-23)

主引用文献

Hu, Y.,Wang, Y.,Deng, J.,Jiang, H.
The structure of a prophenoloxidase (PPO) from Anopheles gambiae provides new insights into the mechanism of PPO activation.
Bmc Biol., 14:2-2, 2016

PubMed Abstract: Phenoloxidase (PO)-catalyzed melanization is a universal defense mechanism of insects against pathogenic and parasitic infections. In mosquitos such as Anopheles gambiae, melanotic encapsulation is a resistance mechanism against certain parasites that cause malaria and filariasis. PO is initially synthesized by hemocytes and released into hemolymph as inactive prophenoloxidase (PPO), which is activated by a serine protease cascade upon recognition of foreign invaders. The mechanisms of PPO activation and PO catalysis have been elusive.

PubMed: 26732497
DOI: 10.1186/s12915-015-0225-2

実験手法

X-RAY DIFFRACTION (2.6 Å)