4YZU
Rapid development of two Factor IXa inhibitors from Hit to Lead
Summary for 4YZU
Entry DOI | 10.2210/pdb4yzu/pdb |
Related | 4Z0K |
Descriptor | Coagulation factor IX, N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide, SODIUM ION, ... (7 entities in total) |
Functional Keywords | serine proteinase, blood coagulation, coagulation factor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted : P00740 P00740 |
Total number of polymer chains | 2 |
Total formula weight | 33572.66 |
Authors | Hruza, A.,Reichert, P. (deposition date: 2015-03-25, release date: 2015-05-20, Last modification date: 2023-09-27) |
Primary citation | Parker, D.L.,Walsh, S.,Li, B.,Kim, E.,Sharipour, A.,Smith, C.,Chen, Y.H.,Berger, R.,Harper, B.,Zhang, T.,Park, M.,Shu, M.,Wu, J.,Xu, J.,Dewnani, S.,Sherer, E.C.,Hruza, A.,Reichert, P.,Geissler, W.,Sonatore, L.,Ellsworth, K.,Balkovec, J.,Greenlee, W.,Wood, H.B. Rapid development of two factor IXa inhibitors from hit to lead. Bioorg.Med.Chem.Lett., 25:2321-2325, 2015 Cited by PubMed: 25937013DOI: 10.1016/j.bmcl.2015.04.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.41 Å) |
Structure validation
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