4YZ2

Crystal Structure of Streptococcus pneumoniae NanC, in complex with 2-deoxy-2,3-didehydro-N-acetylneuraminic acid.

Summary for 4YZ2

Entry DOI	10.2210/pdb4yz2/pdb
Descriptor	Sialidase NanC, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, SULFATE ION, ... (4 entities in total)
Functional Keywords	sialidase, neuraminidase, beta-propeller, cbm40, hydrolase
Biological source	Streptococcus pneumoniae
Total number of polymer chains	2
Total formula weight	153536.83
Authors	Lukacik, P.,Owen, C.D.,Potter, J.A.,Taylor, G.L.,Walsh, M.A. (deposition date: 2015-03-24, release date: 2015-09-23, Last modification date: 2020-07-29)
Primary citation	Owen, C.D.,Lukacik, P.,Potter, J.A.,Sleator, O.,Taylor, G.L.,Walsh, M.A. Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR. J.Biol.Chem., 290:27736-27748, 2015 Cited by PubMed: 26370075 DOI: 10.1074/jbc.M115.673632 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.06 Å)

Structure validation