4YVV

Crystal structure of AKR1C3 complexed with glibenclamide

4YVV の概要

• エントリーDOI: 10.2210/pdb4yvv/pdb
• 関連するPDBエントリー: 4YVP 4YVX
• 分子名称: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... (4 entities in total)
• 機能のキーワード: akr1c3 inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P42330
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76287.28

構造登録者

Zhao, Y.,Zheng, X.,Zhang, H.,Hu, X. (登録日: 2015-03-20, 公開日: 2015-11-25, 最終更新日: 2023-11-08)

主引用文献

Zhao, Y.,Zheng, X.,Zhang, H.,Zhai, J.,Zhang, L.,Li, C.,Zeng, K.,Chen, Y.,Li, Q.,Hu, X.
In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis
Chem.Biol.Interact., 240:310-315, 2015

PubMed Abstract: Recent epidemiological studies show conflicting data for the first-line anti-diabetic sulphonylureas drugs in treating cancer progression in type II diabetes patients. How sulphonylureas promote or diminish tumor growth is not fully understood. Here, we report that seven sulphonylureas exhibit different in vitro inhibition towards AKR1Cs (AKR1C1, AKR1C2, AKR1C3), which are critical steroid hormone metabolism enzymes that are related to prostate cancer, breast cancer and endometrial diseases. Interactions of the sulphonylureas and AKR1Cs were analyzed by X-ray crystallography.

PubMed: 26362498
DOI: 10.1016/j.cbi.2015.09.006

実験手法

X-RAY DIFFRACTION (2.3 Å)