4YNK

Crystal structure of vitamin D receptor ligand binding domain complexed with a 19-norvitamin D compound

4YNK の概要

• エントリーDOI: 10.2210/pdb4ynk/pdb
• 分子名称: Vitamin D3 receptor,Vitamin D3 receptor, Coactivator peptide drip from cDNA FLJ50196, highly similar to Peroxisome proliferator-activated receptor-binding protein, (1R,3R,7E,17beta)-17-{(5S)-5-hydroxy-5-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-1-yl]penta-1,3-diyn-1-yl}-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
• 機能のキーワード: transcription, hormone receptor
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32666.65

構造登録者

Watarai, Y.,Ikura, T.,Ito, N. (登録日: 2015-03-10, 公開日: 2016-01-20, 最終更新日: 2023-11-08)

• 主引用文献: Watarai, Y.,Ishizawa, M.,Ikura, T.,Zacconi, F.C.,Uno, S.,Ito, N.,Mourino, A.,Tokiwa, H.,Makishima, M.,Yamada, S.; Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds; J.Med.Chem., 58:9510-9521, 2015; PubMed: 26613420; DOI: 10.1021/acs.jmedchem.5b00792

実験手法

X-RAY DIFFRACTION (2.3 Å)