4YN8

Crystal Structure of Response Regulator ChrA in Heme-Sensing Two Component System

4YN8 の概要

• エントリーDOI: 10.2210/pdb4yn8/pdb
• 分子名称: Response regulator ChrA, SULFATE ION, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: dna-binding, helix-turn-helix, dna binding protein
• 由来する生物種: Corynebacterium diphtheriae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22193.09

構造登録者

Doi, A.,Nakamura, H.,Shiro, Y.,Sugimoto, H. (登録日: 2015-03-09, 公開日: 2015-08-19, 最終更新日: 2023-11-08)

主引用文献

Doi, A.,Nakamura, H.,Shiro, Y.,Sugimoto, H.
Structure of the response regulator ChrA in the haem-sensing two-component system of Corynebacterium diphtheriae.
Acta Crystallogr.,Sect.F, 71:966-971, 2015

PubMed Abstract: ChrA is a response regulator (RR) in the two-component system involved in regulating the degradation and transport of haem (Fe-porphyrin) in the pathogen Corynebacterium diphtheriae. Here, the crystal structure of full-length ChrA is described at a resolution of 1.8 Å. ChrA consists of an N-terminal regulatory domain, a long linker region and a C-terminal DNA-binding domain. A structural comparison of ChrA with other RRs revealed substantial differences in the relative orientation of the two domains and the conformation of the linker region. The structural flexibility of the linker could be an important feature in rearrangement of the domain orientation to create a dimerization interface to bind DNA during haem-sensing signal transduction.

PubMed: 26249683
DOI: 10.1107/S2053230X15009838

実験手法

X-RAY DIFFRACTION (1.8 Å)