4YKN

Pi3K alpha lipid kinase with Active Site Inhibitor

4YKN の概要

• エントリーDOI: 10.2210/pdb4ykn/pdb
• 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform fusion protein, 3-(6-methoxypyridin-3-yl)-5-[({4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}amino)methyl]benzoic acid (3 entities in total)
• 機能のキーワード: "lipid kinase", inhibitor, complex, pi3k, pi3k alpha, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 163380.02

構造登録者

Elkins, P.A. (登録日: 2015-03-04, 公開日: 2015-06-17, 最終更新日: 2024-02-28)

• 主引用文献: Yang, H.,Medeiros, P.F.,Raha, K.,Elkins, P.,Lind, K.E.,Lehr, R.,Adams, N.D.,Burgess, J.L.,Schmidt, S.J.,Knight, S.D.,Auger, K.R.,Schaber, M.D.,Franklin, G.J.,Ding, Y.,DeLorey, J.L.,Centrella, P.A.,Mataruse, S.,Skinner, S.R.,Clark, M.A.,Cuozzo, J.W.,Evindar, G.; Discovery of a Potent Class of PI3K alpha Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).; Acs Med.Chem.Lett., 6:531-536, 2015; PubMed: 26005528; DOI: 10.1021/acsmedchemlett.5b00025

実験手法

X-RAY DIFFRACTION (2.9 Å)