4YJO

THE KINASE DOMAIN OF HUMAN SPLEEN TYROSINE (SYK) IN COMPLEX WITH GTC000222

4YJO の概要

• エントリーDOI: 10.2210/pdb4yjo/pdb
• 分子名称: Tyrosine-protein kinase SYK, 5-chloro-N~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-N~4~-ethyl-N~4~-(1H-indazol-4-yl)pyrimidine-2,4-diamine, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: syk, non-receptor tyrosine kinase, spleen tyrosine kinase, transferase, phosphorylation, transferase-transferase inhibitor complex
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane : P43405
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33198.67

構造登録者

Somers, D.O.,Neu, M. (登録日: 2015-03-03, 公開日: 2015-09-30)

• 主引用文献: Liddle, J.,Atkinson, F.L.,Barker, M.D.,Carter, P.S.,Curtis, N.R.,Davis, R.P.,Douault, C.,Dickson, M.C.,Elwes, D.,Garton, N.S.,Gray, M.,Hayhow, T.G.,Hobbs, C.I.,Jones, E.,Leach, S.,Leavens, K.,Lewis, H.D.,McCleary, S.,Neu, M.,Patel, V.K.,Preston, A.G.,Ramirez-Molina, C.,Shipley, T.J.,Skone, P.A.,Smithers, N.,Somers, D.O.,Walker, A.L.,Watson, R.J.,Weingarten, G.G.; Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.; Bioorg. Med. Chem. Lett., 21:6188-6194, 2011; PubMed: 21903390; DOI: 10.1016/j.bmcl.2011.07.082

実験手法

X-RAY DIFFRACTION (1.6 Å)