4YJ3

Crystal structure of tubulin bound to compound 2

Summary for 4YJ3

• Entry DOI: 10.2210/pdb4yj3/pdb
• Related: 4YJ2
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, IMIDAZOLE, ... (12 entities in total)
• Functional Keywords: alpha-tubulin, beta-tubulin, stathmin, mi-181, cell cycle inhibitor complex, microtubule, cytoskeleton, cell cycle
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 6
• Total formula weight: 264817.77

Authors

McNamara, D.E.,Torres, J.Z.,Yeates, T.O. (deposition date: 2015-03-03, release date: 2015-05-27, Last modification date: 2023-09-27)

• Primary citation: McNamara, D.E.,Senese, S.,Yeates, T.O.,Torres, J.Z.; Structures of potent anticancer compounds bound to tubulin.; Protein Sci., 24:1164-1172, 2015; PubMed: 25970265; DOI: 10.1002/pro.2704

Experimental method

X-RAY DIFFRACTION (3.75 Å)