4YFF
TNNI3K complexed with inhibitor 2
Summary for 4YFF
Entry DOI | 10.2210/pdb4yff/pdb |
Related | 4YFI |
Descriptor | Serine/threonine-protein kinase TNNI3K, 3-[(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-(morpholin-4-yl)benzenesulfonamide (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q59H18 |
Total number of polymer chains | 4 |
Total formula weight | 141422.81 |
Authors | Shewchuk, L.M.,Wang, L.,Lawhorn, B.G. (deposition date: 2015-02-25, release date: 2015-09-23, Last modification date: 2024-02-28) |
Primary citation | Lawhorn, B.G.,Philp, J.,Zhao, Y.,Louer, C.,Hammond, M.,Cheung, M.,Fries, H.,Graves, A.P.,Shewchuk, L.,Wang, L.,Cottom, J.E.,Qi, H.,Zhao, H.,Totoritis, R.,Zhang, G.,Schwartz, B.,Li, H.,Sweitzer, S.,Holt, D.A.,Gatto, G.J.,Kallander, L.S. Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K). J.Med.Chem., 58:7431-7448, 2015 Cited by PubMed: 26355916DOI: 10.1021/acs.jmedchem.5b00931 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.07 Å) |
Structure validation
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