4YCZ
Y-COMPLEX HUB (NUP85-NUP120-NUP145C-SEC13 COMPLEX) FROM M. THERMOPHILA (A.K.A. T. HETEROTHALLICA)
Summary for 4YCZ
| Entry DOI | 10.2210/pdb4ycz/pdb |
| Descriptor | Fusion Protein of Sec13 and Nup145C, Nup85, Nup120 (3 entities in total) |
| Functional Keywords | structural protein complex, nuclear pore complex, macromolecular assemblies, structural protein |
| Biological source | Thielavia heterothallica More |
| Total number of polymer chains | 3 |
| Total formula weight | 234483.05 |
| Authors | Kelley, K.,Knockenhauer, K.E.,Schwartz, T.U. (deposition date: 2015-02-20, release date: 2015-04-01, Last modification date: 2024-10-23) |
| Primary citation | Kelley, K.,Knockenhauer, K.E.,Kabachinski, G.,Schwartz, T.U. Atomic structure of the Y complex of the nuclear pore. Nat.Struct.Mol.Biol., 22:425-431, 2015 Cited by PubMed Abstract: The nuclear pore complex (NPC) is the principal gateway for transport into and out of the nucleus. Selectivity is achieved through the hydrogel-like core of the NPC. The structural integrity of the NPC depends on ~15 architectural proteins, which are organized in distinct subcomplexes to form the >40-MDa ring-like structure. Here we present the 4.1-Å crystal structure of a heterotetrameric core element ('hub') of the Y complex, the essential NPC building block, from Myceliophthora thermophila. Using the hub structure together with known Y-complex fragments, we built the entire ~0.5-MDa Y complex. Our data reveal that the conserved core of the Y complex has six rather than seven members. Evolutionarily distant Y-complex assemblies share a conserved core that is very similar in shape and dimension, thus suggesting that there are closely related architectural codes for constructing the NPC in all eukaryotes. PubMed: 25822992DOI: 10.1038/nsmb.2998 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (4.1 Å) |
Structure validation
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