4YBL

Crystal structure of the stabilized inner domain of clade A/E HIV-1 gp120 in complex with the ADCC mediating ANTI-HIV-1 antibody A32

Summary for 4YBL

Entry DOI	10.2210/pdb4ybl/pdb
Related	3TNM 4H8W 4RQH 4YC2
Descriptor	Stabilized inner domain of clade A/E gp120, A32 antibody Fab heavy chain, A32 antibody light chain (3 entities in total)
Functional Keywords	adcc, non-neutralizing, anti-hiv-1 env antibody a32, cd4i antibody, viral glycoprotein gp120, hiv-1 env, viral protein-immune system complex, viral protein/immune system
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	6
Total formula weight	126843.38
Authors	Tolbert, W.D.,Gohain, N.,Pazgier, M. (deposition date: 2015-02-18, release date: 2016-03-02, Last modification date: 2023-09-27)
Primary citation	Tolbert, W.D.,Gohain, N.,Veillette, M.,Chapleau, J.P.,Orlandi, C.,Visciano, M.L.,Ebadi, M.,DeVico, A.L.,Fouts, T.R.,Finzi, A.,Lewis, G.K.,Pazgier, M. Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region. Structure, 24:697-709, 2016 Cited by PubMed: 27041594 DOI: 10.1016/j.str.2016.03.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation