4YAQ

Crystal structure of a computationally optimized PG9 mutant

4YAQ の概要

• エントリーDOI: 10.2210/pdb4yaq/pdb
• 分子名称: PG9_N100FY Fab heavy chain, PG9_N100FY Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: antibody, hiv, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 102242.92

構造登録者

Murrell, S.,Julien, J.P.,Wilson, I.A. (登録日: 2015-02-17, 公開日: 2015-06-03, 最終更新日: 2023-11-15)

• 主引用文献: Willis, J.R.,Sapparapu, G.,Murrell, S.,Julien, J.P.,Singh, V.,King, H.G.,Xia, Y.,Pickens, J.A.,LaBranche, C.C.,Slaughter, J.C.,Montefiori, D.C.,Wilson, I.A.,Meiler, J.,Crowe, J.E.; Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.; J.Clin.Invest., 125:2523-2531, 2015; PubMed: 25985274; DOI: 10.1172/JCI80693

実験手法

X-RAY DIFFRACTION (2.3 Å)