4Y8W

Crystal Structure of Human Cytochrome P450 21A2 Progesterone Complex

Summary for 4Y8W

Entry DOI	10.2210/pdb4y8w/pdb
Descriptor	Cytochrome P450 21-hydroxylase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
Functional Keywords	steroid hydroxylation, monooxygenases, adrenal steroidogenesis, congenital adrenal hyperplasia, addison's disease, kinetic isotope effects, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	166794.58
Authors	Pallan, P.S.,Lei, L.,Egli, M. (deposition date: 2015-02-16, release date: 2015-04-15, Last modification date: 2023-09-27)
Primary citation	Pallan, P.S.,Wang, C.,Lei, L.,Yoshimoto, F.K.,Auchus, R.J.,Waterman, M.R.,Guengerich, F.P.,Egli, M. Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE. J.Biol.Chem., 290:13128-13143, 2015 Cited by PubMed: 25855791 DOI: 10.1074/jbc.M115.646307 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.64 Å)

Structure validation