4Y8W
Crystal Structure of Human Cytochrome P450 21A2 Progesterone Complex
Summary for 4Y8W
Entry DOI | 10.2210/pdb4y8w/pdb |
Descriptor | Cytochrome P450 21-hydroxylase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total) |
Functional Keywords | steroid hydroxylation, monooxygenases, adrenal steroidogenesis, congenital adrenal hyperplasia, addison's disease, kinetic isotope effects, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 166794.58 |
Authors | Pallan, P.S.,Lei, L.,Egli, M. (deposition date: 2015-02-16, release date: 2015-04-15, Last modification date: 2023-09-27) |
Primary citation | Pallan, P.S.,Wang, C.,Lei, L.,Yoshimoto, F.K.,Auchus, R.J.,Waterman, M.R.,Guengerich, F.P.,Egli, M. Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE. J.Biol.Chem., 290:13128-13143, 2015 Cited by PubMed: 25855791DOI: 10.1074/jbc.M115.646307 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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