4Y8W

Crystal Structure of Human Cytochrome P450 21A2 Progesterone Complex

4Y8W の概要

• エントリーDOI: 10.2210/pdb4y8w/pdb
• 分子名称: Cytochrome P450 21-hydroxylase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: steroid hydroxylation, monooxygenases, adrenal steroidogenesis, congenital adrenal hyperplasia, addison's disease, kinetic isotope effects, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 166794.58

構造登録者

Pallan, P.S.,Lei, L.,Egli, M. (登録日: 2015-02-16, 公開日: 2015-04-15, 最終更新日: 2023-09-27)

• 主引用文献: Pallan, P.S.,Wang, C.,Lei, L.,Yoshimoto, F.K.,Auchus, R.J.,Waterman, M.R.,Guengerich, F.P.,Egli, M.; Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.; J.Biol.Chem., 290:13128-13143, 2015; PubMed: 25855791; DOI: 10.1074/jbc.M115.646307

実験手法

X-RAY DIFFRACTION (2.64 Å)