4Y8C

Crystal structure of phosphodiesterase 9 in complex with (S)-C33

4Y8C の概要

• エントリーDOI: 10.2210/pdb4y8c/pdb
• 分子名称: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, 6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, ZINC ION, ... (5 entities in total)
• 機能のキーワード: phosphodiesterase 9a, inhibitor selectivity pocket, pharmacokinetics, enantiomeric differentiation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 124473.26

構造登録者

Huang, M. (登録日: 2015-02-16, 公開日: 2015-09-16, 最終更新日: 2024-02-28)

• 主引用文献: Huang, M.,Shao, Y.,Hou, J.,Cui, W.,Liang, B.,Huang, Y.,Li, Z.,Wu, Y.,Zhu, X.,Liu, P.,Wan, Y.,Ke, H.,Luo, H.B.; Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor.; Mol.Pharmacol., 88:836-845, 2015; PubMed: 26316540; DOI: 10.1124/mol.115.099747

実験手法

X-RAY DIFFRACTION (2.7 Å)