4Y6S
Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC134, and manganese
Summary for 4Y6S
Entry DOI | 10.2210/pdb4y6s/pdb |
Related | 4Y67 4Y6P 4Y6R |
Descriptor | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, MANGANESE (II) ION, [(2R)-4-[hydroxy(methyl)amino]-2-(4-methylphenyl)-4-oxobutyl]phosphonic acid, ... (4 entities in total) |
Functional Keywords | enzyme-inhibitor complex, mep pathway, isoprenoid biosynthesis, oxidoreductase |
Biological source | Plasmodium falciparum (isolate 3D7) |
Cellular location | Plastid, apicoplast : Q8IKG4 |
Total number of polymer chains | 2 |
Total formula weight | 97013.33 |
Authors | Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (deposition date: 2015-02-13, release date: 2015-04-01, Last modification date: 2024-05-08) |
Primary citation | Chofor, R.,Sooriyaarachchi, S.,Risseeuw, M.D.,Bergfors, T.,Pouyez, J.,Johny, C.,Haymond, A.,Everaert, A.,Dowd, C.S.,Maes, L.,Coenye, T.,Alex, A.,Couch, R.D.,Jones, T.A.,Wouters, J.,Mowbray, S.L.,Van Calenbergh, S. Synthesis and Bioactivity of beta-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase. J.Med.Chem., 58:2988-3001, 2015 Cited by PubMed: 25781377DOI: 10.1021/jm5014264 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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