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4Y67

Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC176, and manganese

Summary for 4Y67
Entry DOI10.2210/pdb4y67/pdb
Descriptor1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-phenylpentyl]phosphonic acid, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywordsenzyme-inhibitor complex, mep pathway, isoprenoid biosynthesis, oxidoreductase
Biological sourcePlasmodium falciparum
Cellular locationPlastid, apicoplast : Q8IKG4
Total number of polymer chains2
Total formula weight97069.43
Authors
Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (deposition date: 2015-02-12, release date: 2015-04-01, Last modification date: 2024-01-10)
Primary citationChofor, R.,Sooriyaarachchi, S.,Risseeuw, M.D.,Bergfors, T.,Pouyez, J.,Johny, C.,Haymond, A.,Everaert, A.,Dowd, C.S.,Maes, L.,Coenye, T.,Alex, A.,Couch, R.D.,Jones, T.A.,Wouters, J.,Mowbray, S.L.,Van Calenbergh, S.
Synthesis and Bioactivity of beta-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase.
J.Med.Chem., 58:2988-3001, 2015
Cited by
PubMed: 25781377
DOI: 10.1021/jm5014264
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

217705

건을2024-03-27부터공개중

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