4Y67

Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC176, and manganese

4Y67 の概要

• エントリーDOI: 10.2210/pdb4y67/pdb
• 分子名称: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-phenylpentyl]phosphonic acid, MANGANESE (II) ION, ... (4 entities in total)
• 機能のキーワード: enzyme-inhibitor complex, mep pathway, isoprenoid biosynthesis, oxidoreductase
• 由来する生物種: Plasmodium falciparum
• 細胞内の位置: Plastid, apicoplast : Q8IKG4
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97069.43

構造登録者

Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (登録日: 2015-02-12, 公開日: 2015-04-01, 最終更新日: 2024-01-10)

• 主引用文献: Chofor, R.,Sooriyaarachchi, S.,Risseeuw, M.D.,Bergfors, T.,Pouyez, J.,Johny, C.,Haymond, A.,Everaert, A.,Dowd, C.S.,Maes, L.,Coenye, T.,Alex, A.,Couch, R.D.,Jones, T.A.,Wouters, J.,Mowbray, S.L.,Van Calenbergh, S.; Synthesis and Bioactivity of beta-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase.; J.Med.Chem., 58:2988-3001, 2015; PubMed: 25781377; DOI: 10.1021/jm5014264

実験手法

X-RAY DIFFRACTION (1.6 Å)