4Y61

Crystal structure of the complex between Slitrk2 LRR1 and PTP delta Ig1-Fn1

4Y61 の概要

• エントリーDOI: 10.2210/pdb4y61/pdb
• 分子名称: Receptor-type tyrosine-protein phosphatase delta, SLIT and NTRK-like protein 2, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: trans-synaptic complex, hydrolase-signaling protein complex, hydrolase/signaling protein
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75786.10

構造登録者

Yamgata, A.,Sato, Y.,Goto-Ito, S.,Uemura, T.,Maeda, A.,Shiroshima, T.,Yoshida, T.,Fukai, S. (登録日: 2015-02-12, 公開日: 2015-06-03, 最終更新日: 2023-11-08)

主引用文献

Yamagata, A.,Sato, Y.,Goto-Ito, S.,Uemura, T.,Maeda, A.,Shiroshima, T.,Yoshida, T.,Fukai, S.
Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion.
Sci Rep, 5:9686-9686, 2015

PubMed Abstract: Selective binding between pre- and postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) δ. The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation.

PubMed: 25989451
DOI: 10.1038/srep09686

実験手法

X-RAY DIFFRACTION (3.358 Å)