4Y46

Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors

Summary for 4Y46

• Entry DOI: 10.2210/pdb4y46/pdb
• Related: 4Y5H
• Descriptor: Mitogen-activated protein kinase 10, 1-{trans-4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl}-3-propan-2-ylurea (3 entities in total)
• Functional Keywords: jnk, map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P53779
• Total number of polymer chains: 1
• Total formula weight: 42674.47

Authors

Park, H. (deposition date: 2015-02-10, release date: 2015-05-06, Last modification date: 2024-02-28)

• Primary citation: Zheng, K.,Park, C.M.,Iqbal, S.,Hernandez, P.,Park, H.,LoGrasso, P.V.,Feng, Y.; Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.; Acs Med.Chem.Lett., 6:413-418, 2015; PubMed: 25893042; DOI: 10.1021/ml500474d

Experimental method

X-RAY DIFFRACTION (2.04 Å)