4Y3B
Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma
Summary for 4Y3B
Entry DOI | 10.2210/pdb4y3b/pdb |
Descriptor | 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-THR-[H][C@@]1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCCN1C, (2S)-2-(2-methoxyethyl)pyrrolidine, ... (4 entities in total) |
Functional Keywords | 14-3-3 fold, tau, all alpha-helical, adapter protein, protein-protein interaction, peptide binding protein, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 54918.75 |
Authors | Bartel, M.,Milroy, L.G.,Brunsveld, L.,Ottmann, C. (deposition date: 2015-02-10, release date: 2015-12-23, Last modification date: 2024-10-16) |
Primary citation | Milroy, L.G.,Bartel, M.,Henen, M.A.,Leysen, S.,Adriaans, J.M.,Brunsveld, L.,Landrieu, I.,Ottmann, C. Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54:15720-15724, 2015 Cited by PubMed: 26537010DOI: 10.1002/anie.201507976 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report