4Y18

Structure of BRCA1 BRCT domains in complex with Abraxas double phosphorylated peptide

Summary for 4Y18

Entry DOI	10.2210/pdb4y18/pdb
Descriptor	Breast cancer type 1 susceptibility protein, BRCA1-A complex subunit Abraxas (3 entities in total)
Functional Keywords	dna damage response, brct, phosphopeptide, ligase-peptide complex, antitumor protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	16
Total formula weight	217639.58
Authors	Wu, Q.,Blundell, T.L. (deposition date: 2015-02-06, release date: 2016-01-27, Last modification date: 2024-01-10)
Primary citation	Wu, Q.,Paul, A.,Su, D.,Mehmood, S.,Foo, T.K.,Ochi, T.,Bunting, E.L.,Xia, B.,Robinson, C.V.,Wang, B.,Blundell, T.L. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol.Cell, 61:434-448, 2016 Cited by PubMed: 26778126 DOI: 10.1016/j.molcel.2015.12.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation