4Y10

Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4-difluorobutanoic acid

4Y10 の概要

• エントリーDOI: 10.2210/pdb4y10/pdb
• 関連するPDBエントリー: 4Y0Y 4Y0Z 4Y11
• 分子名称: Cationic trypsin, Pancreatic trypsin inhibitor, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: hydrolase inhibitors, digestion, metal-binding, protease, secreted, serine protease, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Bos taurus (Cattle); 詳細
• 細胞内の位置: Secreted, extracellular space: P00760; Secreted: P00974
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30840.50

構造登録者

Loll, B.,Ye, S.,Berger, A.A.,Muelow, U.,Alings, C.,Wahl, M.C.,Koksch, B. (登録日: 2015-02-06, 公開日: 2015-06-24, 最終更新日: 2023-11-15)

• 主引用文献: Ye, S.,Loll, B.,Berger, A.A.,Mulow, U.,Alings, C.,Wahl, M.C.,Koksch, B.; Fluorine teams up with water to restore inhibitor activity to mutant BPTI.; Chem Sci, 6:5246-5254, 2015; PubMed: 29449928; DOI: 10.1039/c4sc03227f

実験手法

X-RAY DIFFRACTION (1.37 Å)