4XZN
Crystal structure of the methylated K125R/V301L AKR1B10 Holoenzyme
Summary for 4XZN
Entry DOI | 10.2210/pdb4xzn/pdb |
Related | 1ZUA |
Descriptor | Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | tim barrel, aldo-keto reductase 1b10, oxidoreductase, holoenzyme, cytosolic |
Biological source | Homo sapiens (Human) |
Cellular location | Lysosome : O60218 |
Total number of polymer chains | 1 |
Total formula weight | 37252.59 |
Authors | Cousido-Siah, A.,Ruiz, F.X.,Mitschler, A.,Podjarny, A. (deposition date: 2015-02-04, release date: 2015-11-18, Last modification date: 2024-01-10) |
Primary citation | Ruiz, F.X.,Cousido-Siah, A.,Porte, S.,Dominguez, M.,Crespo, I.,Rechlin, C.,Mitschler, A.,de Lera, A.R.,Martin, M.J.,de la Fuente, J.A.,Klebe, G.,Pares, X.,Farres, J.,Podjarny, A. Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. Chemmedchem, 10:1989-2003, 2015 Cited by PubMed: 26549844DOI: 10.1002/cmdc.201500393 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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