4XVD

17beta-HSD5 in complex with 4-nitro-2-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}methyl)phenol

4XVD の概要

• エントリーDOI: 10.2210/pdb4xvd/pdb
• 関連するPDBエントリー: 4WDT 4WDU 4WDW 4WDX 4XVE
• 分子名称: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-nitro-2-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}methyl)phenol, ... (4 entities in total)
• 機能のキーワード: aldo-keto reductase inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78204.25

構造登録者

Amano, Y.,Yamaguchi, T.,Niimi, T.,Sakashita, H. (登録日: 2015-01-27, 公開日: 2015-04-15, 最終更新日: 2023-11-08)

• 主引用文献: Amano, Y.,Yamaguchi, T.,Niimi, T.,Sakashita, H.; Structures of complexes of type 5 17 beta-hydroxysteroid dehydrogenase with structurally diverse inhibitors: insights into the conformational changes upon inhibitor binding.; Acta Crystallogr.,Sect.D, 71:918-927, 2015; PubMed: 25849402; DOI: 10.1107/S1399004715002175

実験手法

X-RAY DIFFRACTION (2.81 Å)