4XV1
B-Raf Kinase V600E oncogenic mutant in complex with PLX7904
Summary for 4XV1
Entry DOI | 10.2210/pdb4xv1/pdb |
Related | 4K0I 4K16 4K1A |
Descriptor | Serine/threonine-protein kinase B-raf, N'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-N-ethyl-N-methylsulfuric diamide (3 entities in total) |
Functional Keywords | b-raf, braf, proto-oncogene, v600e, kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 67098.80 |
Authors | |
Primary citation | Zhang, C.,Spevak, W.,Zhang, Y.,Burton, E.A.,Ma, Y.,Habets, G.,Zhang, J.,Lin, J.,Ewing, T.,Matusow, B.,Tsang, G.,Marimuthu, A.,Cho, H.,Wu, G.,Wang, W.,Fong, D.,Nguyen, H.,Shi, S.,Womack, P.,Nespi, M.,Shellooe, R.,Carias, H.,Powell, B.,Light, E.,Sanftner, L.,Walters, J.,Tsai, J.,West, B.L.,Visor, G.,Rezaei, H.,Lin, P.S.,Nolop, K.,Ibrahim, P.N.,Hirth, P.,Bollag, G. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature, 526:583-586, 2015 Cited by PubMed: 26466569DOI: 10.1038/nature14982 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.47 Å) |
Structure validation
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