4XTZ

Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 69 that has a fluorine in place of the ribose 2'OH

4XTZ の概要

• エントリーDOI: 10.2210/pdb4xtz/pdb
• 関連するPDBエントリー: 4XTU 4XTV 4XTW 4XTX 4XTY 4XU0 4XU1 4XU2 4XU3
• 分子名称: Bifunctional ligase/repressor BirA, 9-[2-deoxy-2-fluoro-5-O-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)-beta-D-arabinofuranosyl]-9H-purin-6-amine (3 entities in total)
• 機能のキーワード: biotin-protein ligase, bisubstrate inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58218.07

構造登録者

De la Mora-Rey, T.,Finzel, B.C. (登録日: 2015-01-24, 公開日: 2015-09-02, 最終更新日: 2023-09-27)

• 主引用文献: Bockman, M.R.,Kalinda, A.S.,Petrelli, R.,De la Mora-Rey, T.,Tiwari, D.,Liu, F.,Dawadi, S.,Nandakumar, M.,Rhee, K.Y.,Schnappinger, D.,Finzel, B.C.,Aldrich, C.C.; Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.; J.Med.Chem., 58:7349-7369, 2015; PubMed: 26299766; DOI: 10.1021/acs.jmedchem.5b00719

実験手法

X-RAY DIFFRACTION (1.90000672805 Å)