4XTU

Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor (N-({[(1R,2S,3R,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide)

4XTU の概要

• エントリーDOI: 10.2210/pdb4xtu/pdb
• 関連するPDBエントリー: 4XTV 4XTW 4XTX 4XTY 4XTZ 4XU0 4XU1 4XU2 4XU3
• 分子名称: Bifunctional ligase/repressor BirA, N-({[(1R,2S,3R,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide (3 entities in total)
• 機能のキーワード: biotin-protein ligase, bisubstrate inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58208.17

構造登録者

De la Mora-Rey, T.,Finzel, B.C. (登録日: 2015-01-24, 公開日: 2016-01-13, 最終更新日: 2023-09-27)

• 主引用文献: Bockman, M.R.,Kalinda, A.S.,Petrelli, R.,De la Mora-Rey, T.,Tawari, D.,Liu, F.,Schnappinger, D.,Finzel, B.C.,Aldrich, C.C.; Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor (N-({[(1R,2S,3R,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide); To be Published,

実験手法

X-RAY DIFFRACTION (1.65002988236 Å)