4XT6

Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with the tetrahydropteridine ring of tetrahydrofolate (THF)

4XT6 の概要

• エントリーDOI: 10.2210/pdb4xt6/pdb
• 関連するPDBエントリー: 4XRB 4XT4 4XT5 4XT7 4XT8
• 分子名称: Rv2671, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (6S)-2-amino-6-methyl-5,6,7,8-tetrahydropteridin-4(3H)-one, ... (4 entities in total)
• 機能のキーワード: tetrahydrofolate (thf), reductase, nadp+, structural genomics, tb structural genomics consortium, tbsgc, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28646.09

構造登録者

Sacchettini, J.C.,Cheng, Y.S.,TB Structural Genomics Consortium (TBSGC) (登録日: 2015-01-23, 公開日: 2016-02-24, 最終更新日: 2023-09-27)

• 主引用文献: Cheng, Y.S.,Sacchettini, J.C.; Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.; Biochemistry, 55:1107-1119, 2016; PubMed: 26848874; DOI: 10.1021/acs.biochem.5b00993

実験手法

X-RAY DIFFRACTION (1.85 Å)