4XT1

Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1

4XT1 の概要

• エントリーDOI: 10.2210/pdb4xt1/pdb
• 関連するPDBエントリー: 4XT3
• 分子名称: G-protein coupled receptor homolog US28, Fractalkine, nanobody 7, ... (8 entities in total)
• 機能のキーワード: gpcr, chemokine, membrane protein, complex, viral protein-signalling protein complex, viral protein/signalling protein
• 由来する生物種: Cytomegalovirus; 詳細
• 細胞内の位置: Host cell membrane; Multi-pass membrane protein: P69332; Cell membrane; Single-pass type I membrane protein. Processed fractalkine: Secreted: P78423
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 69666.35

構造登録者

Burg, J.S.,Jude, K.M.,Waghray, D.,Garcia, K.C. (登録日: 2015-01-22, 公開日: 2015-03-04, 最終更新日: 2023-09-27)

• 主引用文献: Burg, J.S.,Ingram, J.R.,Venkatakrishnan, A.J.,Jude, K.M.,Dukkipati, A.,Feinberg, E.N.,Angelini, A.,Waghray, D.,Dror, R.O.,Ploegh, H.L.,Garcia, K.C.; Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.; Science, 347:1113-1117, 2015; PubMed: 25745166; DOI: 10.1126/science.aaa5026

実験手法

X-RAY DIFFRACTION (2.886 Å)