4XSC

Complex structure of thymidylate synthase from varicella zoster virus with a phosphorylated BVDU

Summary for 4XSC

Entry DOI	10.2210/pdb4xsc/pdb
Descriptor	Thymidylate synthase, (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, PENTAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	vzv, thymidylate synthase, herpesvirus, transferase
Biological source	Varicella-zoster virus (strain Oka vaccine) (HHV-3)
Total number of polymer chains	4
Total formula weight	145680.96
Authors	Hew, K. (deposition date: 2015-01-22, release date: 2015-12-16, Last modification date: 2024-01-10)
Primary citation	Hew, K.,Dahlroth, S.L.,Veerappan, S.,Pan, L.X.,Cornvik, T.,Nordlund, P. Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine. Plos One, 10:e0143947-e0143947, 2015 Cited by PubMed: 26630264 DOI: 10.1371/journal.pone.0143947 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.901 Å)

Structure validation