4XSC
Complex structure of thymidylate synthase from varicella zoster virus with a phosphorylated BVDU
Summary for 4XSC
Entry DOI | 10.2210/pdb4xsc/pdb |
Descriptor | Thymidylate synthase, (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, PENTAETHYLENE GLYCOL, ... (4 entities in total) |
Functional Keywords | vzv, thymidylate synthase, herpesvirus, transferase |
Biological source | Varicella-zoster virus (strain Oka vaccine) (HHV-3) |
Total number of polymer chains | 4 |
Total formula weight | 145680.96 |
Authors | |
Primary citation | Hew, K.,Dahlroth, S.L.,Veerappan, S.,Pan, L.X.,Cornvik, T.,Nordlund, P. Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine. Plos One, 10:e0143947-e0143947, 2015 Cited by PubMed: 26630264DOI: 10.1371/journal.pone.0143947 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.901 Å) |
Structure validation
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