4XS1

Salmonella typhimurium AhpC T43V mutant

Summary for 4XS1

• Entry DOI: 10.2210/pdb4xs1/pdb
• Related: 1YEP 4MA9 4XRA 4XRD 4XS4 4XS6 4XS8
• Descriptor: Alkyl hydroperoxide reductase subunit C, POTASSIUM ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: peroxiredoxin, ff, prxi, conformation, oxidoreductase
• Biological source: Salmonella enterica subsp. enterica serovar Typhimurium
• Total number of polymer chains: 5
• Total formula weight: 103586.70

Authors

Perkins, A.,Nelson, K.,Parsonage, D.,Poole, L.,Karplus, P.A. (deposition date: 2015-01-21, release date: 2016-01-27, Last modification date: 2023-09-27)

Primary citation

Nelson, K.J.,Perkins, A.,Van Swearingen, A.E.D.,Hartman, S.,Brereton, A.E.,Parsonage, D.,Salsbury Jr., F.R.,Karplus, P.A.,Poole, L.B.
Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28:521-536, 2018

PubMed Abstract: Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidases involved in oxidant defense and signal transduction. Despite much study, the precise roles of conserved residues remain poorly defined. In this study, we carried out extensive functional and structural characterization of 10 variants of such residues in a model decameric bacterial Prx.

PubMed: 28375740
DOI: 10.1089/ars.2016.6922

Experimental method

X-RAY DIFFRACTION (2.1 Å)