4XRJ
Crystal structure of ERK2 in complex with an inhibitor
Summary for 4XRJ
Entry DOI | 10.2210/pdb4xrj/pdb |
Descriptor | Mitogen-activated protein kinase 1, N~1~-[3-(benzyloxy)benzyl]-1H-tetrazole-1,5-diamine, SULFATE ION, ... (4 entities in total) |
Functional Keywords | serine threonine kinase inhibitor, apoptosis |
Biological source | Rattus norvegicus (Norway Rat) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P63086 |
Total number of polymer chains | 1 |
Total formula weight | 40795.97 |
Authors | Gelin, M.,Allemand, F.,Labesse, G.,Guichou, J.F. (deposition date: 2015-01-21, release date: 2015-08-12, Last modification date: 2015-08-19) |
Primary citation | Gelin, M.,Delfosse, V.,Allemand, F.,Hoh, F.,Sallaz-Damaz, Y.,Pirocchi, M.,Bourguet, W.,Ferrer, J.L.,Labesse, G.,Guichou, J.F. Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71:1777-1787, 2015 Cited by PubMed: 26249358DOI: 10.1107/S1399004715010342 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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