4XQB

CRYSTAL STRUCTURE OF AD37 FIBER KNOB IN COMPLEX WITH TRIVALENT SIALIC ACID INHIBITOR ME0461

4XQB の概要

• エントリーDOI: 10.2210/pdb4xqb/pdb
• 関連するPDBエントリー: 4K6T 4K6U 4K6V 4K6W
• 分子名称: Fiber, 2-(1-{2-[bis(2-{4-[2-({(6R)-5-(acetylamino)-3,5-dideoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-beta-L-threo-hex-2-ulopyranonosyl}oxy)ethyl]-1H-1,2,3-triazol-1-yl}ethyl)amino]ethyl}-1H-1,2,3-triazol-4-yl)ethyl (6R)-5-(acetylamino)-3,5-dideoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-beta-L-threo-hex-2-ulopyranosidonic acid, ZINC ION, ... (5 entities in total)
• 機能のキーワード: adenovirus, fiber knob, protein carbohydrate interaction, sialic acid, carbohydrate mimic, multivalent ligand, viral protein
• 由来する生物種: Human adenovirus 37
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 67132.81

構造登録者

Stehle, T.,Liaci, A.M. (登録日: 2015-01-19, 公開日: 2015-07-29, 最終更新日: 2024-01-10)

• 主引用文献: Caraballo, R.,Saleeb, M.,Bauer, J.,Liaci, A.M.,Chandra, N.,Storm, R.J.,Frangsmyr, L.,Qian, W.,Stehle, T.,Arnberg, N.,Elofsson, M.; Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells.; Org.Biomol.Chem., 13:9194-9205, 2015; PubMed: 26177934; DOI: 10.1039/c5ob01025j

実験手法

X-RAY DIFFRACTION (1.597 Å)