4XQ7
The crystal structure of the OAS-like domain (OLD) of human OASL
Summary for 4XQ7
Entry DOI | 10.2210/pdb4xq7/pdb |
Descriptor | 2'-5'-oligoadenylate synthase-like protein (2 entities in total) |
Functional Keywords | oas, oligoadenylate synthetase, oligoadenylate synthetase-like, oasl, 2'-5' oligoadenylate synthetase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform p56: Nucleus, nucleolus. Isoform p30: Cytoplasm: Q15646 |
Total number of polymer chains | 1 |
Total formula weight | 41807.86 |
Authors | Ibsen, M.S.,Gad, H.H.,Andersen, L.L.,Hornung, V.,Julkunen, I.,Sarkar, S.N.,Hartmann, R. (deposition date: 2015-01-19, release date: 2015-04-22, Last modification date: 2024-01-10) |
Primary citation | Ibsen, M.S.,Gad, H.H.,Andersen, L.L.,Hornung, V.,Julkunen, I.,Sarkar, S.N.,Hartmann, R. Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling. Nucleic Acids Res., 43:5236-5248, 2015 Cited by PubMed: 25925578DOI: 10.1093/nar/gkv389 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report