4XQ7

The crystal structure of the OAS-like domain (OLD) of human OASL

Summary for 4XQ7

Entry DOI	10.2210/pdb4xq7/pdb
Descriptor	2'-5'-oligoadenylate synthase-like protein (2 entities in total)
Functional Keywords	oas, oligoadenylate synthetase, oligoadenylate synthetase-like, oasl, 2'-5' oligoadenylate synthetase, transferase
Biological source	Homo sapiens (Human)
Cellular location	Isoform p56: Nucleus, nucleolus. Isoform p30: Cytoplasm: Q15646
Total number of polymer chains	1
Total formula weight	41807.86
Authors	Ibsen, M.S.,Gad, H.H.,Andersen, L.L.,Hornung, V.,Julkunen, I.,Sarkar, S.N.,Hartmann, R. (deposition date: 2015-01-19, release date: 2015-04-22, Last modification date: 2024-01-10)
Primary citation	Ibsen, M.S.,Gad, H.H.,Andersen, L.L.,Hornung, V.,Julkunen, I.,Sarkar, S.N.,Hartmann, R. Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling. Nucleic Acids Res., 43:5236-5248, 2015 Cited by PubMed: 25925578 DOI: 10.1093/nar/gkv389 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation