4XNE

Crystal structure of ERK2 in complex with an inhibitor

4XNE の概要

• エントリーDOI: 10.2210/pdb4xne/pdb
• 分子名称: Mitogen-activated protein kinase 1, 1-phenyl-1H-1,2,4-triazole-3,5-diamine, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: serine threonine kinase inhibitor, transferase
• 由来する生物種: Rattus norvegicus (Norway Rat)
• 細胞内の位置: Cytoplasm, cytoskeleton, spindle : P63086
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40674.84

構造登録者

Gelin, M.,Allemand, F.,Labesse, G.,Guichou, J.F. (登録日: 2015-01-15, 公開日: 2015-08-12, 最終更新日: 2015-08-19)

• 主引用文献: Gelin, M.,Delfosse, V.,Allemand, F.,Hoh, F.,Sallaz-Damaz, Y.,Pirocchi, M.,Bourguet, W.,Ferrer, J.L.,Labesse, G.,Guichou, J.F.; Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.; Acta Crystallogr.,Sect.D, 71:1777-1787, 2015; PubMed: 26249358; DOI: 10.1107/S1399004715010342

実験手法

X-RAY DIFFRACTION (1.8 Å)