4XJO

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with an inhibitor optimized from HTS lead

4XJO の概要

• エントリーDOI: 10.2210/pdb4xjo/pdb
• 関連するPDBエントリー: 4XJL 4XJM 4XJP
• 分子名称: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 5-[4-(3-chlorobenzoyl)piperazin-1-yl]-1H-inden-1-one, ... (7 entities in total)
• 機能のキーワード: inhibitor complex transaminase plp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98466.54

構造登録者

Finzel, B.C.,Dai, R. (登録日: 2015-01-08, 公開日: 2016-01-20, 最終更新日: 2023-09-27)

• 主引用文献: Liu, F.,Dawadi, S.,Maize, K.M.,Dai, R.,Park, S.W.,Schnappinger, D.,Finzel, B.C.,Aldrich, C.C.; Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.; J. Med. Chem., 60:5507-5520, 2017; PubMed: 28594172; DOI: 10.1021/acs.jmedchem.7b00189

実験手法

X-RAY DIFFRACTION (1.5 Å)