4XHD
STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN WITH COMPOUND-1
Summary for 4XHD
Entry DOI | 10.2210/pdb4xhd/pdb |
Descriptor | Nuclear receptor subfamily 1 group I member 2, GLYCEROL, N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-cyclopropylacetamide, ... (4 entities in total) |
Functional Keywords | pregnane x receptor, pxr, ligand binding domain, steroid receptor coactivator-1; ccr1, chemokine receptor-1; adnectin nr, nuclear receptor; af, activation function; cyp, cytochrome p450; mdr1, multi-drug resistance gene-1., transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : O75469 |
Total number of polymer chains | 1 |
Total formula weight | 36736.88 |
Authors | Khan, J.A.,Camac, D.M. (deposition date: 2015-01-05, release date: 2015-01-28, Last modification date: 2024-02-28) |
Primary citation | Khan, J.A.,Camac, D.M.,Low, S.,Tebben, A.J.,Wensel, D.L.,Wright, M.C.,Su, J.,Jenny, V.,Gupta, R.D.,Ruzanov, M.,Russo, K.A.,Bell, A.,An, Y.,Bryson, J.W.,Gao, M.,Gambhire, P.,Baldwin, E.T.,Gardner, D.,Cavallaro, C.L.,Duncia, J.V.,Hynes, J. Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR. J.Mol.Biol., 427:924-942, 2015 Cited by PubMed: 25579995DOI: 10.1016/j.jmb.2014.12.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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