4XHD

STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN WITH COMPOUND-1

4XHD の概要

• エントリーDOI: 10.2210/pdb4xhd/pdb
• 分子名称: Nuclear receptor subfamily 1 group I member 2, GLYCEROL, N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-cyclopropylacetamide, ... (4 entities in total)
• 機能のキーワード: pregnane x receptor, pxr, ligand binding domain, steroid receptor coactivator-1; ccr1, chemokine receptor-1; adnectin nr, nuclear receptor; af, activation function; cyp, cytochrome p450; mdr1, multi-drug resistance gene-1., transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : O75469
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36736.88

構造登録者

Khan, J.A.,Camac, D.M. (登録日: 2015-01-05, 公開日: 2015-01-28, 最終更新日: 2024-02-28)

• 主引用文献: Khan, J.A.,Camac, D.M.,Low, S.,Tebben, A.J.,Wensel, D.L.,Wright, M.C.,Su, J.,Jenny, V.,Gupta, R.D.,Ruzanov, M.,Russo, K.A.,Bell, A.,An, Y.,Bryson, J.W.,Gao, M.,Gambhire, P.,Baldwin, E.T.,Gardner, D.,Cavallaro, C.L.,Duncia, J.V.,Hynes, J.; Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR.; J.Mol.Biol., 427:924-942, 2015; PubMed: 25579995; DOI: 10.1016/j.jmb.2014.12.022

実験手法

X-RAY DIFFRACTION (2.4 Å)