4XH6

Crystal structure of proto-oncogene kinase Pim1 bound to hispidulin

4XH6 の概要

• エントリーDOI: 10.2210/pdb4xh6/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one (3 entities in total)
• 機能のキーワード: pim1, hispidulin, inhibitor, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34263.78

構造登録者

Su, M.-Y.,Chang, C.-I. (登録日: 2015-01-05, 公開日: 2015-08-26, 最終更新日: 2023-11-08)

• 主引用文献: Chao, S.-W.,Su, M.-Y.,Chiou, L.-C.,Chen, L.-C.,Chang, C.-I.,Huang, W.-J.; Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1; J.Nat.Prod., 78:1969-1976, 2015; PubMed: 26275107; DOI: 10.1021/acs.jnatprod.5b00324

実験手法

X-RAY DIFFRACTION (2.04 Å)