4XEY
Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase
Summary for 4XEY
Entry DOI | 10.2210/pdb4xey/pdb |
Descriptor | Tyrosine-protein kinase ABL1, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (2 entities in total) |
Functional Keywords | tyrosine kinase, kinase domain, sh2 domain, dasatinib, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519 |
Total number of polymer chains | 2 |
Total formula weight | 94696.01 |
Authors | Lorenz, S.,Deng, P.,Kuriyan, J. (deposition date: 2014-12-25, release date: 2015-04-01, Last modification date: 2023-09-27) |
Primary citation | Lorenz, S.,Deng, P.,Hantschel, O.,Superti-Furga, G.,Kuriyan, J. Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity. Biochem.J., 468:283-291, 2015 Cited by PubMed: 25779001DOI: 10.1042/BJ20141492 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.891 Å) |
Structure validation
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