4XEY

Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase

4XEY の概要

• エントリーDOI: 10.2210/pdb4xey/pdb
• 分子名称: Tyrosine-protein kinase ABL1, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (2 entities in total)
• 機能のキーワード: tyrosine kinase, kinase domain, sh2 domain, dasatinib, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 94696.01

構造登録者

Lorenz, S.,Deng, P.,Kuriyan, J. (登録日: 2014-12-25, 公開日: 2015-04-01, 最終更新日: 2023-09-27)

• 主引用文献: Lorenz, S.,Deng, P.,Hantschel, O.,Superti-Furga, G.,Kuriyan, J.; Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.; Biochem.J., 468:283-291, 2015; PubMed: 25779001; DOI: 10.1042/BJ20141492

実験手法

X-RAY DIFFRACTION (2.891 Å)