4XEW
Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a HTS lead compound
Summary for 4XEW
| Entry DOI | 10.2210/pdb4xew/pdb |
| Descriptor | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 6-(2-fluorophenyl)[1,3]dioxolo[4,5-g]quinolin-8(5H)-one, ... (4 entities in total) |
| Functional Keywords | inhibitor complex transaminase plp, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Total number of polymer chains | 2 |
| Total formula weight | 98133.83 |
| Authors | Finzel, B.C.,Dai, R. (deposition date: 2014-12-25, release date: 2015-07-08, Last modification date: 2023-09-27) |
| Primary citation | Dai, R.,Geders, T.W.,Liu, F.,Park, S.W.,Schnappinger, D.,Aldrich, C.C.,Finzel, B.C. Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58:5208-5217, 2015 Cited by PubMed: 26068403DOI: 10.1021/acs.jmedchem.5b00092 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.47 Å) |
Structure validation
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