4XE4

Coagulation Factor XII protease domain crystal structure

4XE4 の概要

• エントリーDOI: 10.2210/pdb4xe4/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900017
• 分子名称: Coagulation factor XII, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: factor xii, zymogens, catalytic domain, active site, blood clotting
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28352.64

構造登録者

Pathak, M.,Wilmann, P.,Awford, J.,Li, C.,Fisher, P.M.,Dreveny, I.,Dekker, L.V.,Emsley, J. (登録日: 2014-12-22, 公開日: 2015-02-04, 最終更新日: 2024-11-06)

主引用文献

Pathak, M.,Wilmann, P.,Awford, J.,Li, C.,Hamad, B.K.,Fischer, P.M.,Dreveny, I.,Dekker, L.V.,Emsley, J.
Coagulation factor XII protease domain crystal structure.
J.Thromb.Haemost., 13:580-591, 2015

PubMed Abstract: Coagulation factor XII is a serine protease that is important for kinin generation and blood coagulation, cleaving the substrates plasma kallikrein and FXI.

PubMed: 25604127
DOI: 10.1111/jth.12849

実験手法

X-RAY DIFFRACTION (2.4 Å)