4XE3

OleP, the cytochrome P450 epoxidase from Streptomyces antibioticus involved in Oleandomycin biosynthesis: functional analysis and crystallographic structure in complex with clotrimazole.

4XE3 の概要

• エントリーDOI: 10.2210/pdb4xe3/pdb
• 分子名称: Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ... (5 entities in total)
• 機能のキーワード: p450, clotrimazole, epoxidase, oleandomycin, oxidoreductase
• 由来する生物種: Streptomyces antibioticus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 92907.42

構造登録者

Montemiglio, L.C.,Parisi, G.,Scaglione, A.,Savino, C.,Vallone, B. (登録日: 2014-12-22, 公開日: 2015-11-04, 最終更新日: 2023-09-27)

主引用文献

Montemiglio, L.C.,Parisi, G.,Scaglione, A.,Sciara, G.,Savino, C.,Vallone, B.
Functional analysis and crystallographic structure of clotrimazole bound OleP, a cytochrome P450 epoxidase from Streptomyces antibioticus involved in oleandomycin biosynthesis.
Biochim.Biophys.Acta, 1860:465-475, 2015

PubMed Abstract: OleP is a cyt P450 from Streptomyces antibioticus carrying out epoxigenation of the antibiotic oleandomycin during its biosynthesis. The timing of its reaction has not been fully clarified, doubts remain regarding its substrate and catalytic mechanism.

PubMed: 26475642
DOI: 10.1016/j.bbagen.2015.10.009

実験手法

X-RAY DIFFRACTION (2.65 Å)