4XDE

Coagulation Factor XII protease domain crystal structure

Summary for 4XDE

Entry DOI	10.2210/pdb4xde/pdb
Descriptor	Coagulation factor XII, ISOPROPYL ALCOHOL, CITRATE ANION, ... (4 entities in total)
Functional Keywords	factor xii, catalytic domain, zymogens, hydrolase, blood clotting
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P00748
Total number of polymer chains	1
Total formula weight	28186.52
Authors	Pathak, M.,Wilmann, P.,Awford, J.,Li, C.,Fisher, P.M.,Dreveny, I.,Dekker, L.V.,Emsley, J. (deposition date: 2014-12-19, release date: 2015-02-04, Last modification date: 2024-11-13)
Primary citation	Pathak, M.,Wilmann, P.,Awford, J.,Li, C.,Hamad, B.K.,Fischer, P.M.,Dreveny, I.,Dekker, L.V.,Emsley, J. Coagulation factor XII protease domain crystal structure. J.Thromb.Haemost., 13:580-591, 2015 Cited by PubMed Abstract: Coagulation factor XII is a serine protease that is important for kinin generation and blood coagulation, cleaving the substrates plasma kallikrein and FXI. PubMed: 25604127 DOI: 10.1111/jth.12849 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation