4XCB

Crystal Structure of HygX from Streptomyces hygroscopicus with nickel, 2-oxoglutarate, and hygromycin B bound

Summary for 4XCB

Entry DOI	10.2210/pdb4xcb/pdb
Descriptor	oxidase/hydroxylase, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ... (5 entities in total)
Functional Keywords	oxidoreductase, double stranded beta helix
Biological source	Streptomyces hygroscopicus subsp. hygroscopicus
Total number of polymer chains	4
Total formula weight	120385.13
Authors	McCulloch, K.M.,McCranie, E.K.,Sarwar, M.,Mathieu, J.L.,Gitschlag, B.L.,Du, Y.,Bachmann, B.O.,Iverson, T.M. (deposition date: 2014-12-17, release date: 2015-08-05, Last modification date: 2023-09-27)
Primary citation	McCulloch, K.M.,McCranie, E.K.,Smith, J.A.,Sarwar, M.,Mathieu, J.L.,Gitschlag, B.L.,Du, Y.,Bachmann, B.O.,Iverson, T.M. Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. Proc.Natl.Acad.Sci.USA, 112:11547-11552, 2015 Cited by PubMed: 26240321 DOI: 10.1073/pnas.1500964112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation